Description
Product Characteristics: SPOP may modulate the transcriptional repression activities of death-associated protein 6 (DAXX), which interacts with histone deacetylase, core histones, and other histone-associated proteins. In mouse, the protein binds to the putative leucine zipper domain of macroH2A1.2, a variant H2A histone that is enriched on inactivated X chromosomes. The BTB/POZ domain of this protein has been shown in other proteins to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes. Synonyms: Polyclonal SPOP antibody, Anti-SPOP antibody, speckle-type POZ protein antibody, TEF2 antibody.
Target Information: In complex with CUL3, involved in ubiquitination and proteasomal degradation of several substrates (By similarity)